Kate del Castillo is wanted for a starring role as a witness.
Mexican authorities have ordered that the actress be located and presented for questioning about her encounters with cartel kingpin Joaquin “El Chapo” Guzman.
Two security officials confirm that federal prosecutors issued the order after the movie and telenovela star did not appear at a previous appointment to give a statement.
They spoke on condition of anonymity because they were not authorized to discuss the matter publicly.
The officials said Thursday that the order applies only to Mexican territory.
Del Castillo, 43, is a naturalized U.S. citizen and has lived for years in Los Angeles.
They added that if del Castillo were found to be in Mexico, she would be detained to make a statement as a witness and then released after doing so.
Del Castillo reportedly brokered the secret meeting between the drug lord and American actor Sean Penn to discuss a possible movie about Guzman’s life.
Penn later wrote about the meeting for Rolling Stone, a meeting authorities say helped them track down the drug kingpin.
The friendship between the telenovela star and “El Chapo” apparently blossomed after she mentioned him in a series of 2012 tweets. Guzman broke out of prison in July, and was captured last month.