United States secretary of state John Kerry broke his right leg in an accident while cycling in the Alps near Scionzier, France, on Sunday and is returning to the United States, his spokesman says.
He has cancelled visits to Madrid and Paris.
Mr Kerry broke his right femur but the injury is not life-threatening and he is expected to make a full recovery, the spokesman said.
He was taken to a Geneva hospital after being injured and was in stable condition.
The accident occurred while Mr Kerry was out cycling after meetings with his Iranian counterpart, Mohammad Javad Zarif, in Geneva to try to overcome obstacles in negotiations on curbing Tehran’s nuclear program.
The talks did not go into a second day as planned after Tehran rejected a key Western demand for site inspections.
Mr Kerry was flown by medical helicopter from the scene of the accident to Geneva’s main public hospital, spokesman John Kirby said.
“The secretary is stable and never lost consciousness, his injury is not life-threatening, and he is expected to make a full recovery,” Mr Kirby said, adding that paramedics and a doctor were on the scene with Mr Kerry’s motorcade at the time of the accident.
“Given the injury is near the site of his prior hip surgery, he will return to Boston today to seek treatment at Massachusetts General Hospital with his doctor who did the prior surgery.”
The 71-year-old secretary of state is an avid cyclist and often takes his own bike on official trips abroad.
A senior State Department official said it appeared Mr Kerry hit a curb and there was no vehicle involved in the accident.
He had been due to travel to Madrid, Spain, later on Sunday before heading to Paris for a meeting with Iraqi prime minister Haidar al-Abadi and members of a US-supported coalition fighting the militant group Islamic State.